The SPRINTT (Sarcopaenia & Physical fRailty iN older people: multi-component Treatment strategies) initiative consists of a large, multi-centre, randomised trial comparing the efficacy of a multi-component intervention (based on long-term structured physical activity and nutritional counselling) versus a Healthy Ageing Lifestyle Education (HALE) programme for preventing disability in older adults with physical frailty and sarcopaenia.

Learn more about this study by contacting us: 

Professor Alan Sinclair (UK Chief Investigator) Diabetes Frail, Medici Medical Practice, Luton
Tel: 01582 738464
[email protected]

The project involves 1500 participants across a total of 14 sites from 9 different countries. The project leader is Professor Roberto Bernabei of Rome, Italy, and other participating sites include:

Site name Country
Università Cattolica del Sacro Cuore (Rome; Co-ordinating Site) Italy
Istituto Nazionale di Riposo e Cura per Anziani (Ancona)
Centre Hospitalier Universitaire de Toulouse (Toulouse) France
Centre Hospitalier Universitaire Limoges (Limoges)
Getafe University Hospital (Madrid) Spain
Hospital Universitario Ramón y Cajal (Madrid)
Friedrich-Alexander Universität Erlangen-Nürnberg (Nurnberg) Germany
University of Hamburg (Hamburg)
Diabetes Frail, Medici Medical Practice (Luton) United Kingdom
Heart Of England NHS Foundation Trust (Birmingham)
Charles University (Prague) Czech Republic
Jagiellonian University Medical College (Krakow) Poland
University of Helsinki Finland
Maastricht University Medical Centre (Maastricht) The Netherlands

Sarcopaenia and frailty

Sarcopaenia is the progressive loss of skeletal muscle mass, strength, and power that occurs with ageing. The cumulative loss of muscle mass can result in reduced ability to perform everyday activities of daily living, subsequently causing deteriorations in quality of life. Sarcopaenia has several other negative consequences and is a major risk factor for falls, frailty and disability. Many of the adverse outcomes associated with frailty are often mediated by sarcopaenia. Therefore, sarcopaenia may be considered both as the biological substrate for the development of frailty and the pathway through which the negative health outcomes of frailty ensue. Lifestyle, mainly lack of exercise and malnutrition, is an important contributor to both frailty and sarcopaenia and can worsen the age associated decline in muscle mass, power and strength. However, both frailty and sarcopaenia are reversible and can be effectively prevented/managed with appropriate exercise and nutrition based intervention.

Key aims

The main aim of SPRINTT is to offer efficient treatment options to older people with frailty and sarcopaenia, and in turn improve their quality of life. The primary objective of the project is to evaluate the effectiveness of a multi-component intervention (MCI) programme (physical activity, nutritional counselling/dietary intervention, and information & communication technology intervention) compared with a HALE programme on the hazard rate of mobility disability, in 1500 non-disabled, community-dwelling individuals over 70 with physical frailty and sarcopaenia. The study will provide information on the prevalence of physical frailty and sarcopaenia among older adults throughout Europe and will test a novel strategy to prevent disability in this vulnerable population.













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